1. 国家基金面上项目,黄瓜花叶病毒复制酶与基因组末端非翻译区组合型协同进化的分子机制,资助年限:2024.01-2027.12,主持。
2. 国家基金面上项目,基于黄瓜花叶病毒的多价弱毒疫苗创制与突变修复机理研究,资助年限:2021.1-2024.12,主持。
3. 国家基金面上项目,小麦黄花叶病毒(WYMV)不依赖帽子翻译调控的差异化调控机制,资助年限:2019.1-2022.12,主持。
4. 国家基金面上项目,烟草丛顶病毒RNA依赖RNA聚合酶(RdRp)的-1型移码翻译机制研究,资助年限:2017.1-2020.12,主持。
5. 国家基金面上项目,烟草丛顶病毒不依赖帽子翻译机制的RNA结构基础解析,资助年限:2014.1-2017.12,主持。
6. 山东省重点研发计划项目:玉米重大病害成灾机制及防控技术研究,资助年限:2023.01-2025.12,课题1负责人。
7. 山东省基金面上项目,烟草丛顶病毒基因组复制调控的RNA结构基础研究,资助年限:2013.10-2016.10,主持。
8. 山东省现代农业产业技术体系-烟草体系副首席、病虫害防控岗位项目,资助年限:2023---(滚续资助),主持。
9. 山东省省级教育专项资金:国家植保微生物种质资源库(山东),资助年限:2023---(滚续资助),主持。
10. 中国烟草总公司云南省公司科技计划项目-重大项目,利用TOM2A基因创制K326抗病毒新品系,资助年限:2022.01-2024.12,协作单位负责人。
11. 山东潍坊烟草有限公司科技计划项目,烟草病毒病多联弱毒疫苗创制与调节剂作用分析,资助年限:2020.01-2022.12,协作单位负责人。
|
1. 论文:在Nucleic Acids Research、RNA、Plant Biotechnology Journal、Journal of Virology 等杂志发表论文70余篇。第一或通讯作者(*)发表的代表性期刊论文如下,#表示并列第一作者, 本人姓名加粗。
l Geng G, Yu C, Yuan X*. 2024. Variable eIF4E-binding sites and their synergistic effect on cap-independent translation in a novel IRES of wheat yellow mosaic virus RNA2 isolates. International Journal of Biological Macromolecules, 254(3):128062
l Liu S#, Su C#, Zhang D, Song Z, Wang X, Wang J*, Yuan X*. 2023. Construction of a delivery platform for vaccine based on modified nanotubes: sustainable prevention against plant viral disease, simplified preparation method, and protection of plasmid. Acs Applied Materials & Interface, 15(37):44541-44553.
l Yang C#, Yu C#, Zhang Z, Wang D*, Yuan X*. 2022. Molecular characteristics of subgenomic RNAs and the cap-dependent translational advantage relative to corresponding genomic RNAs of Tomato spotted wilt virus. International Journal of Molecular Sciences. 23(23):15074.
l Liu S, Mu J, Yu C, Geng G, Su C, Yuan X*. 2022. Multiple levels of triggered factors and the obligated requirement of cell-to-cell movement in the mutation repair of cucumber mosaic virus with defects in the tRNA-like structure. Biology, 11:1051.
l Geng G#, Wang D#, Liu Z, Wang Y, Zhu M, Cao X, Yu C*, Yuan X*. 2021. Translation of plant RNA viruses. Viruses, 13(12):2499.
l Geng G, Yu C, Li X, Yuan X*. 2020. A unique internal ribosome entry site representing a dynamic equilibrium state of RNA tertiary structure in the 5′-UTR of Wheat yellow mosaic virus RNA1. Nucleic Acids Research,48(1): 390-404.
l Cao X #, Liu S #, Yu C, Li X, Yuan X*. 2019. A new strategy of using satellite RNA to control viral plant diseases: Post-inoculation with satellite RNA attenuates symptoms derived from pre-infection with its helper virus. Plant Biotechnology Journal,17(10):1856-1858.
l Yuan X, Shi K, Simon AE. 2012. A local, interactive network of 3’ RNA elements supports translation and replication of Turnip Crinkle Virus. Journal of Virology 86 (8): 4065-4081.
l Yuan X, Shi K, Meskauskas A, Simon AE. 2009. The 3′ end of Turnip Crinkle Virus contains a highly interactive structure including a translational enhancer that is disrupted by binding to the RNA-dependent RNA polymerase. RNA 15(10): 1849-1864.
2. 专利;第一完成人获国家发明专利8项,澳大利亚革新专利1项
3. 科研奖励:第十届淮海科学技术将二等奖(2023,第1位)。
|